Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR−/− mice
نویسندگان
چکیده
منابع مشابه
Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.
Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1, Akt2, and Akt3, but the roles of Akt1 and Akt2 in atherosclerosis in vivo remain unclear. To dissect the impact of macrophage Akt1 and Akt2 on early atherosclerosis, we genera...
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OBJECTIVE Leukocyte recruitment is a major contributor in the development of atherosclerosis and requires a variety of proteins such as adhesion molecules, chemokines, and chemokine receptors. Several key molecular players implicated in this process are expressed on monocytes and require protein-tyrosine sulfation for optimal function in vitro, including human CCR2, CCR5, CX3CR1, and PSGL-1. We...
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Chronic kidney disease (CKD) leads to uremia. CKD is characterized by a gradual increase in kidney fibrosis and loss of kidney function, which is associated with a progressive increase in risk of atherosclerosis and cardiovascular death. To prevent progression of both kidney fibrosis and atherosclerosis in uremic settings, insight into new treatment options with effects on both parameters is wa...
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RATIONALE Carboxylesterase 3/triacylglycerol hydrolase (TGH) has been shown to participate in hepatic very low-density lipoprotein (VLDL) assembly. Deficiency of TGH in mice lowers plasma lipids and atherogenic lipoproteins without inducing hepatic steatosis. OBJECTIVE To investigate the contribution of TGH to atherosclerotic lesion development in mice that lack low-density lipoprotein recept...
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This study was designed to compare the effects of D-tagatose with BSN272 on serum lipids and prevention of atherosclerosis in LDLr mice. BSN272 is a combination drug of D-tagatose and polydatin (trans piceid). LDLr mice were divided into four groups and were all fed a standard chow. Mice were dosed by gavage and received water (group 1), a glucose/fructose mixture (group 2), or glucose/fructose...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2015
ISSN: 0969-7128,1476-5462
DOI: 10.1038/gt.2015.78